Development of a device to automatically deliver antidotes for opioid overdose
User-centric development of closed-loop therapy for opioid overdose
This study is testing a new device that can automatically give naloxone to someone who is having trouble breathing from an opioid overdose, making it easier to save lives during those crucial moments, and it’s designed with input from patients and doctors to make sure it’s something people would want to use.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rescue Biomedical, LLC NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11306118 on NIH RePORTER |
What this research studies
This research focuses on creating an automatic antidote delivery device (A2D2) that can detect opioid-induced respiratory failure and administer naloxone without user intervention. The device aims to address the critical time window during an overdose when immediate action is necessary to prevent death. By collaborating with healthcare professionals, the project seeks to understand user preferences for wearable and implantable devices, ensuring that the solution is both effective and acceptable to patients. The goal is to enhance survival rates for individuals experiencing opioid overdoses by providing timely medical intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of opioid overdose, including those with a history of opioid use or dependency.
Not a fit: Patients who do not use opioids or are not at risk of overdose may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of deaths from opioid overdoses by providing immediate treatment.
How similar studies have performed: Other research has shown promise in developing automated systems for drug delivery, indicating potential success for this novel approach.
Where this research is happening
West Lafayette, United States
- Rescue Biomedical, LLC — West Lafayette, United States (Active)
Researchers
- Principal investigator: Le, Vy — Rescue Biomedical, LLC
- Study coordinator: Le, Vy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.