Developing vaccines to reduce HIV in children and youth
Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccines
This study is testing a new type of vaccine to help children and young people aged 9 to 25 who have been on HIV medication and are doing well, with the goal of reducing the hidden HIV in their bodies, and some participants will also receive an extra treatment to boost their immune system.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10800760 on NIH RePORTER |
What this research studies
This research aims to create therapeutic vaccines using prime-boost HIVIS DNA and MVA-CMDR to target and reduce HIV reservoirs in children and youth. The study will involve children aged 9 to 25 years who have been on HIV medications since early childhood and are currently virally suppressed. Participants will receive either the therapeutic vaccines alone or in combination with a TLR4 agonist to enhance immune responses. The study will take place over 72 weeks in South Africa, with a total of 25 participants enrolled.
Who could benefit from this research
Good fit: Ideal candidates are children and youth aged 9 to 25 years who have been on HIV treatment since before 6 months of age and are currently virally suppressed.
Not a fit: Patients who are not virally suppressed or have not started HIV medications early in life may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective therapeutic vaccines that significantly reduce HIV reservoirs in children, improving their long-term health outcomes.
How similar studies have performed: While this approach is novel in the pediatric population, similar therapeutic vaccine strategies have shown promise in adult populations.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Robb, Merlin L — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Robb, Merlin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.