Developing vaccines to protect against SARS-CoV-2 variants
Mucosal subunit vaccines against SARS CoV-2
This study is testing a new type of vaccine that aims to provide long-lasting protection against COVID-19 by boosting your immune response, and it's designed for anyone interested in better ways to fight off the virus and its variants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11106030 on NIH RePORTER |
What this research studies
This research focuses on creating mucosal vaccines that can effectively combat SARS-CoV-2 variants by generating long-lasting immunity. It aims to enhance both cell-mediated and humoral immune responses, which are crucial for protection against respiratory infections. The study explores the use of a novel adjuvant, Bordetella Colonization Factor A (BcfA), which promotes a more effective immune response compared to traditional adjuvants like alum. By targeting the immune system's T follicular helper cells and memory B cells, the research seeks to improve the durability of vaccine-induced protection.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk of COVID-19 infection.
Not a fit: Patients who are not at risk for COVID-19 or those who have already been vaccinated with effective vaccines may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide long-lasting protection against COVID-19 variants.
How similar studies have performed: Other research has shown promise in developing vaccines with novel adjuvants, indicating potential for success with this approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Dubey, Purnima — Ohio State University
- Study coordinator: Dubey, Purnima
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.