Developing vaccines to protect against common viral infections
Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential
This study is working on developing new vaccines to protect against picornaviruses, which can cause serious illnesses like polio and brain infections, using cutting-edge methods to find the best options for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10863346 on NIH RePORTER |
What this research studies
This research focuses on creating effective vaccines against picornaviruses, which are known to cause serious illnesses like poliomyelitis and encephalitis. The team will utilize innovative methods, including mRNA and protein-based vaccine candidates, to combat these viruses. By testing these candidates in laboratory settings and animal models, the researchers aim to identify promising options for human use. The project seeks to address the lack of approved antiviral treatments for enterovirus infections, which have significant pandemic potential.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for enterovirus infections, such as children and those with weakened immune systems.
Not a fit: Patients who are not at risk for enterovirus infections or those who have already been vaccinated against these viruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of vaccines that protect against severe viral infections, potentially saving lives and reducing disease burden.
How similar studies have performed: Previous research has shown promise in developing vaccines for similar viral infections, indicating that this approach could be effective.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Semler, Bert L — University of California-Irvine
- Study coordinator: Semler, Bert L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.