Developing vaccines to fight cervical cancer caused by HPV variants.
Official title: Strategies to Reduce Global Health Disparities in Cervical Cancer
Funded at Johns Hopkins University · NIH-11027718 · Data updated 2026-11-12
This study is looking at new vaccines to help fight cervical cancer caused by different types of the HPV16 virus, so that patients can get treatments that work better for their specific virus variant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $630,506 |
| NIH project number | 1R01CA295696-01 |
| Project ID | NIH-11027718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cervical cancer associated with HPV, particularly those with variants of HPV16.
✕Less likely to help
Patients with cervical cancer not associated with HPV or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on creating innovative immunotherapeutic vaccines specifically targeting cervical cancers linked to different variants of the HPV16 virus. By utilizing advanced models of HPV cervicovaginal carcinoma, the team aims to understand how these variants affect immune responses and cancer progression. The study will explore the unique characteristics of HPV16 variants found in diverse populations, which may influence the effectiveness of existing vaccines. Patients may benefit from tailored treatments that are more effective against their specific HPV variant.
Why it matters
Potential benefit: If successful, this research could lead to more effective cervical cancer vaccines that are tailored to different HPV variants, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in developing HPV-targeted immunotherapies, but this approach focusing on variant-specific responses is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wu, Tzyy-Choou — Johns Hopkins University
- Study coordinator: Wu, Tzyy-Choou
Related research
Other NIH-funded projects on the same topics.
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Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
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Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
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Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
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HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
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Hybrid approach to boost cervical cancer screening in Uganda
A tested, community-driven program helps Ugandan women encourage their peers to get free VIA cervical cancer screening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.