Developing vaccines and antibodies for rubulaviruses
Official title: Prototype strategy for vaccines and antibodies to rubulaviruses
Funded at Washington University · NIH-10863698 · Data updated 2026-11-12
This study is working on developing better vaccines to protect against rubulaviruses, which can spread easily and cause respiratory illnesses, by looking closely at how the virus works and how our immune system responds, so we can create stronger defenses for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $5,674,171 |
| NIH project number | 1U19AI181984-01 |
| Project ID | NIH-10863698 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at risk of infection from rubulaviruses or those who may benefit from enhanced vaccine strategies.
✕Less likely to help
Patients who are not at risk for rubulavirus infections or who have already been vaccinated against these viruses may not receive direct benefits from this research.
What this research studies
This research focuses on creating effective vaccines and antibodies to combat rubulaviruses, which are highly transmissible respiratory pathogens. The team will study the structure and function of specific viral proteins to design stabilized vaccine candidates. They will use advanced techniques, including cryoelectron tomography, to understand how these proteins interact with the virus and the immune system. By isolating and characterizing immune cells from vaccinated individuals, they aim to enhance the design of these vaccines and assess their effectiveness in animal models.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines and treatments for diseases caused by rubulaviruses, potentially improving public health outcomes.
How similar studies have gone: Previous research has shown promise in developing vaccines for similar viral pathogens, indicating that this approach could yield successful outcomes.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Duprex, William Paul — Washington University
- Study coordinator: Duprex, William Paul
Related research
Other NIH-funded projects on the same topics.
-
Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain
This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about
-
Advanced Methods & Modeling for Better Patient Care
A funding opportunity focused on developing new modeling methods to improve health care for patients through better data use and analytics.
-
Advanced methods and modeling for health research at Washington University
A health research grant at Washington University funds new modeling methods to support future patient-focused studies.
-
Center for Research in Emerging Infectious Diseases: Epidemiology, Surveillance and Pathogenesis
A NIH program will study and monitor emerging viruses from the Midwest U.S. and three Asian sites to understand how they spread and affect people.
-
How Poverty and the Environment Affect Heart Disease in Haiti and Beyond
This grant studies how poverty-related factors like food insecurity, stress, and pollution contribute to heart disease and aims to follow a large group of adults to better understand and prevent the disease.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.