Developing vaccines and antibodies for respiratory viruses
Official title: Prototype strategies for antibodies and vaccines for respiroviruses
Funded at Washington University · NIH-10863697 · Data updated 2026-11-12
This study is looking at a virus that causes respiratory infections to help create better vaccines and treatments, and it's for anyone interested in how we can improve protection against colds and similar illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $5,035,895 |
| NIH project number | 1U19AI181984-01 |
| Project ID | NIH-10863697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for respiratory infections, such as young children, the elderly, or those with compromised immune systems.
✕Less likely to help
Patients with respiratory infections caused by viruses other than respiroviruses may not benefit from this research.
What this research studies
This research focuses on the human parainfluenza virus type 3 (HPIV3) to create effective vaccines and therapeutic antibodies against respiratory viruses. By studying the structure and function of viral surface proteins, researchers aim to identify optimal targets for immunity. The project will utilize advanced imaging techniques like cryo-electron microscopy to understand how these proteins interact during viral entry into cells. Additionally, different vaccine platforms will be evaluated to determine the best way to present these antigens to the immune system.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines and treatments for respiratory viral infections, potentially reducing illness and hospitalizations.
How similar studies have gone: Previous research has shown promise in developing vaccines and antibodies for similar viral infections, indicating a potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Moscona, Anne — Washington University
- Study coordinator: Moscona, Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.