Developing vaccines against certain viruses that can cause severe illness.
Official title: Design and development of generalizable countermeasures against prototype Phenuiviruses
Funded at Washington University · NIH-10863700 · Data updated 2026-11-12
This study is looking at certain viruses that can cause serious illnesses, like Rift Valley fever and Toscana virus, to find ways to create vaccines that could help protect people from these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 11, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $5,220,489 |
| NIH project number | 1U19AI181984-01 |
| Project ID | NIH-10863700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals at risk of infections from Phenuiviruses, particularly those living in endemic regions.
✕Less likely to help
Patients who are not at risk of exposure to Phenuiviruses or those with existing immunity to these viruses may not receive benefit from this research.
What this research studies
This research focuses on understanding prototype viruses that belong to the Phenuiviridae family, specifically Rift Valley fever virus and Toscana virus. By studying these viruses, the researchers aim to identify common features that could lead to the development of effective vaccines. The project will utilize advanced techniques in structural biology and biochemistry to explore the viral proteins and their potential as targets for medical countermeasures. Patients may benefit from this research as it seeks to create vaccines that could protect against serious viral infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of vaccines that protect against severe viral infections caused by Phenuiviruses.
How similar studies have gone: Other research has shown promise in developing vaccines against prototype pathogens, indicating that this approach could yield significant advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Hartman, Amy L — Washington University
- Study coordinator: Hartman, Amy L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.