Developing ultra-stable insulin analogs for diabetes treatment
Molecular endocrinology and principles of diabetes therapeutics: application to ultra-stable insulin analogs
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10439592
This study is looking at new types of insulin that are more stable and safer to use, which could help people with Type 1 and Type 2 diabetes manage their condition better with devices like insulin pumps.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10439592 on ClinicalTrials.gov |
What this research studies
This research focuses on creating ultra-stable insulin analogs that could improve the safety and effectiveness of insulin delivery systems for diabetes management. By investigating the molecular structure and function of these insulin variants, the team aims to enhance the stability of insulin formulations, making them safer for use in devices like intraperitoneal pumps. The approach involves designing insulin analogs with specific structural features that prevent thermal inactivation while maintaining their biological activity. This could lead to better treatment options for both Type 1 and Type 2 diabetes patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Type 1 or Type 2 diabetes who require insulin therapy.
Not a fit: Patients who do not use insulin or have diabetes that is managed without insulin therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more reliable and safer insulin therapies, improving diabetes management.
How similar studies have performed: Previous research has shown promise in developing stable insulin formulations, suggesting that this approach could lead to significant advancements in diabetes treatment.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, MICHAEL AARON — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WEISS, MICHAEL AARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.