Developing treatments to reduce long-term brain damage from organophosphate poisoning
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
This study is looking for better ways to help people who have been poisoned by organophosphates, which can cause serious long-term brain problems, by trying out new treatments that reduce inflammation and protect the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10991772 on NIH RePORTER |
What this research studies
This research focuses on finding new therapies to help patients who have suffered from acute organophosphate (OP) poisoning, which can lead to serious long-term neurological issues. The team at UC Davis aims to enhance existing treatments by adding new strategies that reduce brain inflammation, protect the blood-brain barrier, and stabilize nerve cell activity. By testing various therapeutic candidates and approaches, they hope to improve the long-term outcomes for individuals affected by OP exposure. This research is particularly important as current treatments are often insufficient for preventing lasting damage unless administered immediately after exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 who have experienced acute organophosphate intoxication, whether from accidents or other exposures.
Not a fit: Patients who have not been exposed to organophosphates or those with chronic neurological conditions unrelated to acute poisoning may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients who experience neurological consequences from organophosphate poisoning.
How similar studies have performed: While there have been studies on organophosphate poisoning, this specific approach to mitigating long-term neurological effects through novel therapeutic strategies is relatively novel and untested.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lein, Pamela J — University of California at Davis
- Study coordinator: Lein, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.