Developing treatments to reduce long-term brain damage from organophosphate poisoning
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
This study is looking for better ways to help people who have been poisoned by organophosphates, aiming to improve their recovery and protect their brain health in the long run.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10991771 on NIH RePORTER |
What this research studies
This research focuses on finding new therapeutic strategies to help patients who have experienced acute organophosphate (OP) poisoning, which can lead to serious long-term neurological issues. The approach involves enhancing standard treatments by adding therapies that aim to reduce brain inflammation, protect the blood-brain barrier, and stabilize neuronal activity. The research is structured into three main projects, each targeting different aspects of brain protection and recovery. By improving these treatments, the goal is to enhance the long-term outcomes for individuals affected by OP poisoning.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 years old who have experienced acute organophosphate intoxication.
Not a fit: Patients who have not been exposed to organophosphate compounds or those with chronic neurological conditions unrelated to OP poisoning may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients suffering from the neurological effects of organophosphate poisoning.
How similar studies have performed: While there have been studies on treatments for organophosphate poisoning, this specific approach to mitigating long-term neurological consequences is relatively novel and untested.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lein, Pamela J — University of California at Davis
- Study coordinator: Lein, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.