Developing treatments to reduce long-term brain damage from organophosphate poisoning
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
This study is looking for better ways to help people who have been poisoned by organophosphates, by adding new treatments to the usual care to reduce brain swelling and protect brain function, with the goal of improving their long-term recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10911228 on NIH RePORTER |
What this research studies
This research focuses on finding new therapeutic strategies to help patients who have suffered from acute organophosphate (OP) poisoning. The approach involves enhancing standard treatments with additional therapies aimed at reducing brain inflammation, protecting the blood-brain barrier, and normalizing brain activity. By addressing these factors, the research aims to improve long-term neurological outcomes for individuals affected by OP exposure. The project includes multiple research initiatives that will test various therapeutic candidates and strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced acute organophosphate intoxication, particularly those at risk of long-term neurological effects.
Not a fit: Patients who have not been exposed to organophosphate compounds or those with pre-existing neurological conditions unrelated to OP exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the long-term neurological damage experienced by patients after organophosphate poisoning.
How similar studies have performed: While there have been studies on acute organophosphate poisoning, this research aims to develop novel approaches that have not been extensively tested before.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lein, Pamela J — University of California at Davis
- Study coordinator: Lein, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.