Developing tools to target specific structures in RNA
Synthetic strategies for non-canonical hybridization to structural motifs in RNA
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10922682
This study is looking at new ways to create special tiny proteins that can stick to unique shapes in RNA, which could help us better understand how RNA works and lead to new treatments for various conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10922682 on ClinicalTrials.gov |
What this research studies
This research focuses on creating synthetic peptide-based binders that can selectively attach to unique structural motifs found in RNA. By synthesizing a small library of these reagents, the researchers aim to evaluate their effectiveness in binding to non-canonical RNA structures through innovative functional screening methods in laboratory settings. The goal is to enhance our understanding of RNA biology and potentially develop new therapeutic tools that can modulate RNA functions. This approach seeks to overcome current limitations in targeting RNA by exploring non-canonical interactions that have been largely overlooked.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions linked to non-canonical RNA structures, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to RNA or those whose diseases do not involve non-canonical RNA structures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic tools that improve the treatment of diseases related to RNA dysfunction.
How similar studies have performed: While the approach of targeting non-canonical RNA structures is relatively novel, similar strategies in synthetic biology have shown promise in other areas of RNA research.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BONG, DENNIS — OHIO STATE UNIVERSITY
- Study coordinator: BONG, DENNIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.