Developing tools to study the human epigenome and its variations
Official title: Tooling for accurately studying the epigenome along the human pangenome reference
Funded at University of Washington · NIH-10976065 · Data updated 2026-11-12
This study is working on new tools to better understand how our genes and their chemical tags affect health, which could help patients learn more about their own genetic makeup and its connection to different health issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,418,806 |
| NIH project number | 1U01HG013744-01 |
| Project ID | NIH-10976065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with specific genetic variants or those interested in understanding their epigenetic information.
✕Less likely to help
Patients without significant genetic variants or those not interested in genetic and epigenetic analysis may not receive direct benefits from this research.
What this research studies
This research focuses on creating advanced tools to accurately annotate and analyze the epigenetic elements within the human pangenome reference. By integrating both long-read and short-read epigenetic data, the project aims to enhance our understanding of how genetic variants function within the pangenome. Patients may benefit from improved insights into their genetic makeup and how it relates to various health conditions. The methodology involves assembling precise epigenetic annotations and threading them into a comprehensive pangenome reference, allowing for better compatibility with existing genetic analysis tools.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments based on individual genetic and epigenetic profiles.
How similar studies have gone: Other research has shown success in utilizing similar approaches to enhance genetic understanding, making this a promising area of investigation.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Stergachis, Andrew Ben — University of Washington
- Study coordinator: Stergachis, Andrew Ben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.