Developing tools to study epilepsy using stem cells
Human Epilepsy Tools Core (HETC)
This study is exploring how special stem cells can help us learn more about epilepsy by creating models that reflect the genetic differences linked to the condition, which could lead to better understanding and treatment options for people with epilepsy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10873152 on NIH RePORTER |
What this research studies
This research focuses on creating and utilizing human embryonic and induced pluripotent stem cells to better understand epilepsy. The team will develop specific stem cell models that mimic genetic variations associated with epilepsy, allowing for detailed study of these conditions. By deriving patient-specific stem cell lines from blood or skin samples, researchers aim to optimize methods for differentiating these cells into neurons. This work will provide essential resources for ongoing epilepsy research and improve the understanding of the genetic factors involved in the disease.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with epilepsy or those who have a family history of epilepsy, particularly those willing to provide blood or skin samples.
Not a fit: Patients without epilepsy or those who do not have a genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for epilepsy based on individual genetic profiles.
How similar studies have performed: Previous research using stem cell models has shown promise in understanding various neurological disorders, indicating a strong potential for success in this area as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Dang, Louis Tuong Chinh — University of Michigan at Ann Arbor
- Study coordinator: Dang, Louis Tuong Chinh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.