Developing tools to deliver genes to specific brain cells using machine learning
Machine Learning Augmented Discovery of AAV Capsids for Cell Type Specific Access into Human Neurons and Glia
This study is working on new ways to deliver genes to specific brain cells, like neurons, to help us better understand how they work and improve treatments for brain-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10512547 on NIH RePORTER |
What this research studies
This research focuses on creating advanced tools to genetically target and access specific types of cells in the human brain, particularly neurons and glial cells. By utilizing machine learning and viral engineering techniques, the project aims to develop novel adeno-associated viral (AAV) vectors that can deliver genes to distinct cell types in the human forebrain, including the hippocampus. The goal is to enhance our understanding of brain cell functions and support various applications in neuroscience. The tools developed will be made available for broader use after thorough validation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may benefit from advancements in gene therapy for neurological conditions.
Not a fit: Patients with conditions unrelated to the targeted brain cell types or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for studying and treating neurological conditions by enabling precise gene delivery to targeted brain cells.
How similar studies have performed: Other research has shown promise in using machine learning and viral vectors for targeted gene delivery, indicating a potential for success in this novel approach.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Schaffer, David V — University of California Berkeley
- Study coordinator: Schaffer, David V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.