Developing tools to control inflammation in the brain
Official title: Genetic circuits for targeted modulation of neuroinflammation
Funded at Central Michigan University · NIH-10811068 · Data updated 2026-11-12
This study is exploring a new way to help manage inflammation in the brain, which is important for people with Alzheimer's disease, by creating smart sensors that can track and respond to inflammation in real-time, potentially leading to better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | September 13, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $348,373 |
| NIH project number | 1R21EB034494-01A1 |
| Project ID | NIH-10811068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions characterized by neuroinflammation.
✕Less likely to help
Patients with neurodegenerative diseases not primarily driven by neuroinflammation may not benefit from this research.
What this research studies
This research focuses on understanding and managing neuroinflammation, which is crucial in conditions like Alzheimer's disease. The team aims to create innovative biosensors that can monitor and regulate inflammation in real-time within the brains of live animals. By utilizing synthetic gene circuits, they plan to develop a system that can detect inflammatory signals and respond by producing proteins that help reduce inflammation. This approach could lead to more effective treatments for neurodegenerative diseases by providing a way to control inflammation dynamically.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage neuroinflammation, potentially improving outcomes for patients with Alzheimer's disease.
How similar studies have gone: While the approach of using biosensors for real-time monitoring of inflammation is innovative, similar methodologies have shown promise in other areas of biomedical research.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Rossignol, Julien — Central Michigan University
- Study coordinator: Rossignol, Julien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.