Developing tools to control inflammation in the brain
Genetic circuits for targeted modulation of neuroinflammation
['FUNDING_R21'] · CENTRAL MICHIGAN UNIVERSITY · NIH-10811068
This study is exploring a new way to help manage inflammation in the brain, which is important for people with Alzheimer's disease, by creating smart sensors that can track and respond to inflammation in real-time, potentially leading to better treatments.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CENTRAL MICHIGAN UNIVERSITY (nih funded) |
| Locations | 1 site (MOUNT PLEASANT, UNITED STATES) |
| Trial ID | NIH-10811068 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding and managing neuroinflammation, which is crucial in conditions like Alzheimer's disease. The team aims to create innovative biosensors that can monitor and regulate inflammation in real-time within the brains of live animals. By utilizing synthetic gene circuits, they plan to develop a system that can detect inflammatory signals and respond by producing proteins that help reduce inflammation. This approach could lead to more effective treatments for neurodegenerative diseases by providing a way to control inflammation dynamically.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions characterized by neuroinflammation.
Not a fit: Patients with neurodegenerative diseases not primarily driven by neuroinflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage neuroinflammation, potentially improving outcomes for patients with Alzheimer's disease.
How similar studies have performed: While the approach of using biosensors for real-time monitoring of inflammation is innovative, similar methodologies have shown promise in other areas of biomedical research.
Where this research is happening
MOUNT PLEASANT, UNITED STATES
- CENTRAL MICHIGAN UNIVERSITY — MOUNT PLEASANT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSSIGNOL, JULIEN — CENTRAL MICHIGAN UNIVERSITY
- Study coordinator: ROSSIGNOL, JULIEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease