Developing therapies to restore vision after nerve injury
VRC: Develop regenerative therapies for neurological vision loss
This study is looking at ways to help older nerve cells in the optic nerve heal better after an injury, which can help improve vision, by tweaking certain genes and proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10686123 on NIH RePORTER |
What this research studies
This research aims to enhance the ability of mature neurons in the optic nerve to regenerate after injury, which can lead to vision loss. The approach involves manipulating specific genes, such as inhibiting let-7 and increasing the activity of lin28 and lin41, to promote axon regeneration and improve visual function. Additionally, the study will explore the role of the TACC3 protein in stimulating growth dynamics of nerve cells. By targeting these pathways, the research seeks to overcome the natural decline in regeneration capacity that occurs with age.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced optic nerve injuries.
Not a fit: Patients with vision loss not related to optic nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore vision in individuals with optic nerve injuries.
How similar studies have performed: While the specific approach is novel, previous research has shown promise in enhancing nerve regeneration through genetic manipulation.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Li, Shuxin — Temple Univ of the Commonwealth
- Study coordinator: Li, Shuxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.