Developing therapies to reduce allergic reactions in asthma patients
Induction of cells and pathways that promote respiratory tolerance in allergic asthma
This study is looking at how certain immune cells can help your body get used to allergens and reduce asthma symptoms, with the goal of finding better treatments for people with respiratory inflammation and allergic asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10471259 on NIH RePORTER |
What this research studies
This research aims to create improved treatments for respiratory inflammation and allergic asthma by exploring how certain immune cells can promote tolerance to allergens. The study focuses on a specific type of immune cell known as tolerogenic plasmacytoid dendritic cells (tolpDCs), which have shown the ability to induce regulatory T cells that can help prevent allergic responses. By investigating the mechanisms behind these cells, researchers hope to find ways to reprogram the immune system to reduce asthma symptoms and improve patient outcomes. The research involves both pre-clinical models and human blood samples to ensure the findings are applicable to real-world scenarios.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic asthma who are seeking new treatment options.
Not a fit: Patients with non-allergic asthma or those whose asthma is not related to specific allergens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that provide long-term relief from asthma symptoms and reduce the need for ongoing medication.
How similar studies have performed: Previous research has shown promise in using tolerogenic immune cells to manage allergic responses, indicating that this approach could be effective.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Akbari, Omid — University of Southern California
- Study coordinator: Akbari, Omid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.