Developing therapies to overcome cancer drug resistance
Cell State Network-Directed Therapy
This study is looking at how cancer cells change to resist treatments, and it's for anyone affected by cancer, as it aims to find better ways to help patients respond to drugs and avoid resistance by using smart computer models to predict the best treatment combinations.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-10986564 on NIH RePORTER |
What this research studies
This research focuses on understanding how cancer cells adapt and become resistant to treatments. By studying the different states that cancer cells can exist in, the researchers aim to create therapies that promote drug-sensitive states while minimizing the chances of resistance. The approach involves using computational models to predict how cancer cells will respond to various drug combinations, which could lead to more effective treatment strategies tailored to individual patients. This innovative method seeks to address the challenge of drug resistance in a proactive manner rather than reactively.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are currently undergoing treatment and may be experiencing or at risk of drug resistance.
Not a fit: Patients with non-cancerous conditions or those who are not currently receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that reduce the likelihood of drug resistance.
How similar studies have performed: Other research has shown promise in using computational models to predict cancer treatment responses, indicating that this approach has potential for success.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Birtwistle, Marc R. — Clemson University
- Study coordinator: Birtwistle, Marc R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.