Developing tests to identify molecules that can kill HIV-infected cells
Official title: HIV Assay Development and Testing to Identify Targeted Activator of Cell Kill Molecules
Funded at Research Triangle Institute · NIH-11161830 · Data updated 2026-11-12
This study is looking for new ways to help kill HIV-infected cells by testing certain medications, which could lead to better treatment options for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $391,596 |
| NIH project number | 75N93021D00004-0-759302400001-1 |
| Project ID | NIH-11161830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals living with HIV who may be seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are not responsive to NNRTIs may not receive any benefit from this research.
What this research studies
This research focuses on developing and testing assays to identify targeted activators that can kill cells infected with HIV. By establishing a phenotypic assay, the research aims to evaluate the effectiveness of known Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) in activating these cell-kill mechanisms. The approach involves both basic research and preclinical product development, ultimately aiming to advance promising candidates into clinical trials. Patients may benefit from new therapeutic options that emerge from this innovative research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively eliminate HIV-infected cells, improving outcomes for patients living with HIV.
How similar studies have gone: Other research has shown promise in developing targeted therapies for HIV, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Maitra, Rangan — Research Triangle Institute
- Study coordinator: Maitra, Rangan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.