Developing tests to identify cancer risks in the gastrointestinal tract
Biomarker Development Laboratory
This study is looking for specific DNA markers in colon and esophagus samples to help find people at high risk for colorectal cancer and esophageal adenocarcinoma, so we can catch these cancers earlier and improve survival rates.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10884388 on NIH RePORTER |
What this research studies
This research aims to discover and validate biomarkers that can help reduce mortality from gastrointestinal cancers, specifically colorectal cancer and esophageal adenocarcinoma. The approach involves identifying specific DNA markers in colon and esophageal samples that indicate a higher risk of cancer. Patients at high risk for colorectal cancer will be identified for aggressive screening, while biomarkers for early detection of esophageal adenocarcinoma will be developed using non-invasive methods. The goal is to create cost-effective surveillance programs that can lead to earlier diagnosis and better outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for colorectal cancer or those with Barrett's esophagus who may develop esophageal adenocarcinoma.
Not a fit: Patients with no history of gastrointestinal cancers or those not at risk for these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of gastrointestinal cancers, significantly improving survival rates.
How similar studies have performed: Previous research has shown promise in using biomarkers for cancer detection, indicating that this approach could be effective.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.