Developing tests to ensure the safety of gene editing therapies
Validated Immunoassays to Accelerate Therapeutic Genome Editing INDs
This study is working on new tests to check how your immune system reacts to gene editing treatments before they are given to people, helping to make sure these therapies are safe and effective.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11145386 on NIH RePORTER |
What this research studies
This research focuses on creating validated immunoassays to monitor the immune response to gene editing therapies before they are tested in humans. By using advanced techniques like cytokine flow cytometry and multiplex immunoassays, the study aims to measure T-cell immunity and antibody responses to gene editing proteins. This will help ensure the safety and effectiveness of these therapies as they move from laboratory studies to clinical trials. The research will also utilize imaging techniques to track immune responses in living organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may benefit from gene editing therapies, such as genetic disorders or certain cancers.
Not a fit: Patients who do not have conditions that could be treated with gene editing therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer gene editing therapies for a variety of diseases.
How similar studies have performed: Previous research has shown promise in using immunoassays for monitoring immune responses in gene therapy, indicating that this approach is both relevant and potentially effective.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Tarantal, Alice F — University of California at Davis
- Study coordinator: Tarantal, Alice F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.