Developing tests for early detection of ovarian cancer using uterine lavage samples
Biomarker Reference Laboratory (BRL)
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10674914
This study is working on new tests that look for signs of ovarian cancer early by examining samples from the uterus, and it's designed for women who want better ways to catch this cancer sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10674914 on ClinicalTrials.gov |
What this research studies
This research focuses on creating advanced genomic and proteomic tests to detect ovarian cancer at an early stage by analyzing uterine lavage samples. The approach involves assessing genome-wide methylation patterns and measuring specific proteins through proximity extension assays. The tests will be refined using samples from a training cohort, and machine learning techniques will be employed to enhance the accuracy of the results. The goal is to establish reliable biomarkers that can be used in clinical settings for early diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are at risk for ovarian cancer or those presenting with symptoms suggestive of the disease.
Not a fit: Patients who have already been diagnosed with advanced ovarian cancer may not benefit from this early detection research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of ovarian cancer, improving treatment outcomes and survival rates for patients.
How similar studies have performed: Previous research has shown promise in using similar genomic and proteomic approaches for cancer detection, indicating potential for success in this novel application.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KULASINGAM, VATHANY — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: KULASINGAM, VATHANY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.