Developing technology to study DNA modifications related to cancer and other biological processes
Official title: DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION
Funded at Johns Hopkins University · NIH-10870413 · Data updated 2026-11-12
This study is all about developing new tools to better understand a special DNA change called ADP-ribosylation, which is important for fixing DNA and fighting off infections, and it aims to find out where this change happens in our genes to help us learn more about its role in diseases like cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $204,688 |
| NIH project number | 1R21GM154218-01 |
| Project ID | NIH-10870413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or genetic disorders related to DNA repair mechanisms.
✕Less likely to help
Patients with conditions unrelated to DNA modifications or those not affected by cancer may not benefit from this research.
What this research studies
This research focuses on creating new technologies to explore ADP-ribosylation, a DNA modification that plays a crucial role in DNA repair, genome replication, and defense against pathogens. The researchers aim to identify the specific sites of ADP-ribosylation across the entire genome, which has been challenging with existing methods. By utilizing advanced sequencing techniques, they hope to gain a better understanding of how this modification affects biological functions and its implications for diseases, including cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into DNA repair mechanisms and potential therapeutic targets for cancer treatment.
How similar studies have gone: Previous research has shown promise in studying DNA modifications, but this approach to ADP-ribosylation is relatively novel and untested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Leung, Anthony K L — Johns Hopkins University
- Study coordinator: Leung, Anthony K L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.