Developing technologies to improve sleep and monitor behavior in Alzheimer's disease models
Noninvasive sleep enhancement and behavior monitoring technologies for Alzheimer's model mice
This study is looking at new ways to track sleep and wake patterns in mice with Alzheimer's to better understand how sleep issues affect the disease, and it also explores methods to improve sleep that might help clear harmful proteins from the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Signal Solutions, LLC NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10863907 on NIH RePORTER |
What this research studies
This research focuses on creating innovative technologies to detect and monitor sleep and wake abnormalities in mouse models of Alzheimer's disease. By utilizing a noninvasive piezoelectric system, the project aims to automate the tracking of sleep patterns in rodents, which can provide insights into the progression of Alzheimer's. The study also explores sleep enhancement techniques that may help improve brain waste clearance, particularly targeting the aggregation of harmful proteins associated with Alzheimer's. This approach could lead to better understanding and potential interventions for sleep disturbances commonly seen in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early signs of Alzheimer's disease or those experiencing sleep disturbances related to cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without sleep-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for monitoring and enhancing sleep in Alzheimer's patients, potentially slowing disease progression.
How similar studies have performed: Other research has shown promise in using non-pharmacological approaches to enhance sleep, indicating potential success for this novel approach.
Where this research is happening
Lexington, United States
- Signal Solutions, LLC — Lexington, United States (Active)
Researchers
- Principal investigator: O'hara, Bruce Frederick — Signal Solutions, LLC
- Study coordinator: O'hara, Bruce Frederick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.