Developing targeted therapies for aggressive prostate cancer
Official title: Multimodal dendrimer theranostics targeting aggressive subtypes of prostate cancer
Funded at Ut Southwestern Medical Center · NIH-10977964 · Data updated 2026-11-12
This study is exploring a new way to diagnose and treat aggressive prostate cancer by using special agents that target a specific protein in the cancer cells, which could lead to more effective treatments with fewer side effects for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $692,072 |
| NIH project number | 1R01CA285792-01A1 |
| Project ID | NIH-10977964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with aggressive prostate cancer, particularly those with metastatic disease expressing prostate-specific membrane antigen (PSMA).
✕Less likely to help
Patients with non-aggressive prostate cancer or those who do not express PSMA may not benefit from this research.
What this research studies
This research aims to create a new platform for diagnosing and treating aggressive prostate cancer using specialized agents that target a specific protein associated with the disease. By utilizing poly(amidoamine) dendrimers, the study focuses on delivering both imaging and therapeutic agents directly to cancer cells, which could improve treatment effectiveness while minimizing side effects. The approach involves advanced imaging techniques and targeted therapies that have shown promise in previous trials. Patients may benefit from more precise and effective treatment options tailored to their specific cancer characteristics.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatment options for patients with aggressive prostate cancer.
How similar studies have gone: Previous research has shown success with similar PSMA-targeted therapies, indicating a promising avenue for further development.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Pomper, Martin G — Ut Southwestern Medical Center
- Study coordinator: Pomper, Martin G
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.