Developing targeted gene delivery methods for studying brain function and behavior
Cell type specific AAVs to study reward and cognition
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10517904
This study is working on developing special viruses that can deliver genes directly to specific brain cells, which could lead to better treatments for brain-related issues like reward and thinking problems, helping patients get more personalized and effective therapies in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10517904 on ClinicalTrials.gov |
What this research studies
This research focuses on creating advanced adeno-associated viruses (AAVs) that can specifically target different cell types in the brain. By using a combination of genetic techniques and data from nonhuman primates, the researchers aim to enhance the precision of gene delivery, which is crucial for understanding brain functions related to reward and cognition. The study involves defining specific genetic elements that can drive targeted gene expression, ultimately laying the groundwork for future clinical applications. Patients may benefit from improved gene therapy strategies that are more effective and tailored to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that could benefit from targeted gene therapy.
Not a fit: Patients with conditions unrelated to neurological function or those who do not respond to gene therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for neurological conditions, enhancing treatment options for patients.
How similar studies have performed: Other research has shown promise in using targeted gene delivery methods, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STAUFFER, WILLIAM RICHARD — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: STAUFFER, WILLIAM RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.