Developing systems to mimic human testis development
Organizing and Reorganizing Human Testis Development In Vitro
['FUNDING_R01'] · MAGEE-WOMEN'S RES INST AND FOUNDATION · NIH-10934359
This study is exploring new ways to grow human testes and produce sperm outside the body to help people who might struggle with infertility after cancer treatments or gender-affirming procedures, using special tissues from their testicles.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAGEE-WOMEN'S RES INST AND FOUNDATION (nih funded) |
| Locations | 1 site (Pittsburgh, UNITED STATES) |
| Trial ID | NIH-10934359 on ClinicalTrials.gov |
What this research studies
This research focuses on creating advanced systems that replicate the development of human testes and the process of sperm production outside the body. It aims to help patients who may face infertility due to cancer treatments or gender-affirming procedures by utilizing immature testicular tissues. By studying these tissues, researchers hope to gain insights into testis development and create new technologies that could enable future reproductive options for patients. The project involves collaboration between multiple institutions and aims to establish benchmarks for evaluating progress in this innovative area.
Who could benefit from this research
Good fit: Ideal candidates for this research include prepubertal boys and transgender individuals undergoing gender-affirming treatments who have immature testicular tissues.
Not a fit: Patients who are not at risk of infertility or those who have already completed their reproductive years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new reproductive options for patients who are at risk of infertility due to medical treatments.
How similar studies have performed: Other research has shown promise in similar approaches, particularly in the cryopreservation and maturation of immature testicular tissues.
Where this research is happening
Pittsburgh, UNITED STATES
- MAGEE-WOMEN'S RES INST AND FOUNDATION — Pittsburgh, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORWIG, KYLE EDWIN — MAGEE-WOMEN'S RES INST AND FOUNDATION
- Study coordinator: ORWIG, KYLE EDWIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.