Developing stable insulin analogs for diabetes treatment
Therapeutic Protein Engineering of Single-Chain Insulin Analogs
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10455764
This study is working on a new type of insulin that doesn't need to be kept cold, making it easier for people with diabetes to store and use, and it aims to create different kinds of insulin that work quickly or last longer, which could really help with managing their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10455764 on ClinicalTrials.gov |
What this research studies
This research focuses on creating ultra-stable single-chain insulin analogs that can be used to treat diabetes mellitus. The approach involves designing insulin formulations that are resistant to heat, which could eliminate the need for refrigeration during storage and transport. By utilizing advanced molecular design techniques, the researchers aim to develop rapid-acting, long-acting, and biphasic insulin formulations that can be used in various delivery systems, including implanted insulin pumps. This innovative method could significantly improve the management of diabetes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who require insulin therapy.
Not a fit: Patients with type 2 diabetes who do not require insulin or those who are not insulin-dependent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible insulin treatments for individuals with diabetes.
How similar studies have performed: Previous research has shown promise in developing stable insulin formulations, indicating that this approach has potential for success.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, MICHAEL AARON — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WEISS, MICHAEL AARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus, diabetes, Insulin-Dependent Diabetes Mellitus, Brittle Diabetes Mellitus, Juvenile-Onset Diabetes Mellitus