Developing small tags to improve protein functionality
Official title: Minimal Protein Affinity Tags
Funded at Trinity University · NIH-10203453 · Data updated 2026-11-12
This study is looking at new tiny tags made of just 1-2 building blocks that can help make proteins easier to purify and work better for medical treatments, so they can be more effective for people who need them.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trinity University NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $428,303 |
| NIH project number | 1R15GM141708-01 |
| Project ID | NIH-10203453 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals requiring protein-based treatments, such as those with certain genetic disorders or conditions that involve protein deficiencies.
✕Less likely to help
Patients who do not require protein-based therapies or those with conditions unrelated to protein functionality may not benefit from this research.
What this research studies
This research focuses on creating minimal protein affinity tags that consist of just 1-2 amino acids. These tags are designed to enhance the purification and functionality of proteins, making them more effective for various biomedical applications. The approach involves using small synthetic receptors that can bind to these tags with high affinity, allowing for easy modification and release of proteins in physiological conditions. By optimizing these tags and integrating them into existing protein pharmaceuticals, the research aims to improve the performance of therapeutic proteins.
Why it matters
Potential benefit: If successful, this research could lead to more effective and versatile protein-based therapies for patients.
How similar studies have gone: Previous research has shown promise in using affinity tags for protein modification, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Trinity University
San Antonio, United States Active
Researchers
- Principal investigator: Urbach, Adam Robert — Trinity University
- Study coordinator: Urbach, Adam Robert
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Developing small tags to improve protein functionality
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.