Developing small tags to improve protein functionality
Minimal Protein Affinity Tags
This study is looking at new tiny tags made of just 1-2 building blocks that can help make proteins easier to purify and work better for medical treatments, so they can be more effective for people who need them.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trinity University NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10203453 on NIH RePORTER |
What this research studies
This research focuses on creating minimal protein affinity tags that consist of just 1-2 amino acids. These tags are designed to enhance the purification and functionality of proteins, making them more effective for various biomedical applications. The approach involves using small synthetic receptors that can bind to these tags with high affinity, allowing for easy modification and release of proteins in physiological conditions. By optimizing these tags and integrating them into existing protein pharmaceuticals, the research aims to improve the performance of therapeutic proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals requiring protein-based treatments, such as those with certain genetic disorders or conditions that involve protein deficiencies.
Not a fit: Patients who do not require protein-based therapies or those with conditions unrelated to protein functionality may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and versatile protein-based therapies for patients.
How similar studies have performed: Previous research has shown promise in using affinity tags for protein modification, suggesting that this approach could yield significant advancements.
Where this research is happening
San Antonio, United States
- Trinity University — San Antonio, United States (Active)
Researchers
- Principal investigator: Urbach, Adam Robert — Trinity University
- Study coordinator: Urbach, Adam Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.