Developing small molecules to prevent tau protein aggregation in Alzheimer's disease
Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent model
This study is looking at new tiny molecules that could help stop a harmful protein linked to Alzheimer's disease from clumping together, with the hope that this could lead to better treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11126815 on NIH RePORTER |
What this research studies
This research focuses on creating small molecules that can inhibit the aggregation of hyperphosphorylated tau protein, which is a key factor in Alzheimer's disease. The project involves optimizing these molecules for their pharmaceutical properties and testing them in a rodent model to assess their effectiveness. The principal investigator, Dr. Jessica Fortin, aims to enhance drug discovery techniques and develop a deeper understanding of how these compounds can impact Alzheimer's pathology. Patients may benefit from advancements in treatment options that target the underlying mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to tau protein aggregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting tau aggregation, indicating that this approach may lead to significant advancements in Alzheimer's treatment.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Fortin, Jessica — Purdue University
- Study coordinator: Fortin, Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.