Developing small molecules to improve cancer treatment by targeting CD47
Quantitative High Throughput Screening for Small Molecules Targeting CD47 in Cancer
This study is looking for new tiny medicines that can help your immune system fight cancer better by blocking a specific interaction between two proteins, which could lead to more effective treatments with fewer side effects for people with tumors.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institut Jean Paoli & Irene Calmettes Centre Regional de Lutte Contre Le Cancer NIH-funded |
| Lab location | 1 site (Marseille 9e Arrondissement, France) |
| Project ID | NIH-10557909 on NIH RePORTER |
What this research studies
This research focuses on developing small molecules that can effectively block the interaction between the immune checkpoint protein CD47 and its receptor SIRPα, which is crucial for enhancing the body's anti-tumor immune response. By targeting this interaction, the research aims to improve the selectivity of treatments for tumors while reducing side effects like anemia. The approach involves high throughput screening to identify promising small molecules that can penetrate solid tumors more effectively and lead to better treatment outcomes for cancer patients. If successful, this could provide a new avenue for cancer immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors or hematological cancers that express high levels of CD47.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not express CD47 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic cancer treatments for patients.
How similar studies have performed: Other research has shown promise in targeting immune checkpoints with small molecules, but this specific approach targeting CD47 is relatively novel.
Where this research is happening
Marseille 9e Arrondissement, France
- Institut Jean Paoli & Irene Calmettes Centre Regional de Lutte Contre Le Cancer — Marseille 9e Arrondissement, France (Active)
Researchers
- Principal investigator: Miller, Thomas W — Institut Jean Paoli & Irene Calmettes Centre Regional de Lutte Contre Le Cancer
- Study coordinator: Miller, Thomas W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.