Developing small molecules to block a protein linked to breast cancer spread
Official title: Small Molecule Inhibitors of the Inflammatory Cytokine Oncostatin M
Funded at Boise State University · NIH-10438068 · Data updated 2026-11-12
This study is working on developing new medications that can help stop the spread of breast cancer by blocking a specific protein called oncostatin M, which is linked to cancer growth, with the hope of improving treatment options for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise State University NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project start | April 18, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $395,436 |
| NIH project number | 1R15CA271157-01 |
| Project ID | NIH-10438068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those at risk of metastasis due to high levels of OSM.
✕Less likely to help
Patients with non-cancerous conditions or those without elevated OSM levels may not benefit from this research.
What this research studies
This research focuses on creating small molecule inhibitors that target and block the inflammatory cytokine oncostatin M (OSM), which is associated with breast cancer metastasis. By inhibiting OSM signaling, the project aims to prevent the early stages of tumor spread, potentially improving outcomes for patients diagnosed with breast cancer. The approach involves synthesizing these inhibitors and testing their effectiveness through advanced biological assays. If successful, this could lead to new FDA-approved treatments that protect against the progression of breast cancer.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option that significantly reduces the risk of breast cancer metastasis.
How similar studies have gone: While the approach of targeting OSM is promising, it is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
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Boise State University
Boise, United States Active
Researchers
- Principal investigator: Warner, Don L — Boise State University
- Study coordinator: Warner, Don L
Related research
Other NIH-funded projects on the same topics.
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Healthy Idaho Clinical & Translational Research Development Program
A multi-institution effort in Idaho to build clinical and translational research capacity and workforce to address local health needs.
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Healthy Idaho Health Research Core supports translational projects
A Boise State University program funds and guides health research projects in Idaho to turn ideas into bigger health improvements for local communities.
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Healthy Idaho Clinical and Translational Research Design and Data Management
A program to strengthen how clinical and translational studies are planned, run, and using health data across Idaho, helping researchers design better studies and use EHR data responsibly.
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Healthy Idaho community engagement for translational research
A Boise State University program aims to strengthen ties between researchers and Idaho communities to support research that meets local health needs.
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Healthy Idaho professional development for clinical and translational research
A program to help Idaho investigators build skills and mentoring networks to conduct high-quality clinical and translational research.
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Healthy Idaho Clinical & Translational Research Development Administrative Core
A funded administrative core in Idaho helps coordinate and support clinical and translational research to improve health across the state.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.