Developing sensors to measure metabolic signaling in cells
Official title: Localized Real-time Sensors for Metabolic Signaling
Funded at University of Texas at Austin · NIH-10764520 · Data updated 2026-11-12
This study is looking at how changes in certain substances in our cells can affect how they work and communicate, using special tools that light up to show these changes, which could help find new ways to treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $381,480 |
| NIH project number | 1R35GM152218-01 |
| Project ID | NIH-10764520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or diseases influenced by cellular signaling.
✕Less likely to help
Patients with conditions unrelated to metabolic signaling may not benefit from this research.
What this research studies
This research focuses on understanding how metabolic pathways influence cellular signaling and gene expression. By creating small, genetically encoded fluorescent biosensors, the project aims to accurately measure the concentrations of specific metabolites within cells. These sensors will allow researchers to observe how fluctuations in metabolite levels affect cellular functions and signaling pathways. This could lead to new strategies for treating diseases by targeting metabolic processes.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that modulate cell metabolism to combat various diseases.
How similar studies have gone: Other research has shown promise in using biosensors for metabolic studies, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Cambronne, Xiaolu Ang — University of Texas at Austin
- Study coordinator: Cambronne, Xiaolu Ang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.