Developing sensors to measure a specific protein involved in cancer treatment.
Official title: A design strategy to quantify unconjugated Nedd8 using genetically encoded sensors.
Funded at Black Hills State University · NIH-10876196 · Data updated 2026-11-12
This study is working on a special tool that can measure a protein called Nedd8, which is important in cancer, to help us learn more about its role in the disease and possibly find new ways to treat cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Black Hills State University NIH-funded |
| Lab location | 1 site (Spearfish, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $383,091 |
| NIH project number | 1R15GM154230-01 |
| Project ID | NIH-10876196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with solid tumor cancers that may be influenced by Nedd8 regulation.
✕Less likely to help
Patients with cancers not related to Nedd8 or those who are not undergoing treatment for solid tumors may not benefit from this research.
What this research studies
This research focuses on creating genetically encoded sensors that can detect and quantify free Nedd8, a protein that plays a crucial role in regulating cancer-related processes. The approach involves designing a sensor that minimizes interference with the protein's natural function while providing accurate measurements. By monitoring free Nedd8 levels in cells, this research aims to enhance our understanding of its role in cancer and potentially aid in the development of new cancer therapies. The findings could lead to broader applications for creating sensors for other important biological targets.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and treating certain types of cancer.
How similar studies have gone: Previous research has shown success in using genetically encoded sensors for other proteins, indicating potential for this novel approach.
Where this research is happening
-
Black Hills State University
Spearfish, United States Active
Researchers
- Principal investigator: Choi, Yun Seok — Black Hills State University
- Study coordinator: Choi, Yun Seok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.