Developing RNA sensors to target cancer cells
Official title: Cancer Classifiers Based on RNA Sensors in Living Cells
Funded at Stanford University · NIH-10884363 · Data updated 2026-11-12
This study is working on special tools that can find cancer-related signals in living cells, so we can deliver treatments directly to cancer cells and help the immune system fight them better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $231,600 |
| NIH project number | 5R21EB033858-03 |
| Project ID | NIH-10884363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with specific types of cancer that exhibit unique RNA markers.
✕Less likely to help
Patients with cancers that do not have identifiable RNA markers or those who are not eligible for genetic therapies may not benefit from this research.
What this research studies
This research focuses on creating RNA sensors that can be used in living mammalian cells to detect specific cancer-related RNA markers. By genetically engineering these sensors, the goal is to deliver therapeutic proteins directly to cancer cells based on their unique transcriptional profiles. This innovative approach aims to enhance cancer treatment by not only targeting cancer cells for destruction but also training the immune system to recognize and eliminate other cancer cells. The methodology involves using genetic circuits that can sense cellular states and respond accordingly, potentially transforming cancer therapy.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted cancer treatments that minimize damage to healthy cells.
How similar studies have gone: Previous research has shown promise in using RNA-based approaches for cancer detection and treatment, indicating that this method could be a significant advancement in the field.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Gao, Xiaojing J — Stanford University
- Study coordinator: Gao, Xiaojing J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.