Developing RNA sensors to target cancer cells
Cancer Classifiers Based on RNA Sensors in Living Cells
['FUNDING_R21'] · STANFORD UNIVERSITY · NIH-10884363
This study is working on special tools that can find cancer-related signals in living cells, so we can deliver treatments directly to cancer cells and help the immune system fight them better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10884363 on ClinicalTrials.gov |
What this research studies
This research focuses on creating RNA sensors that can be used in living mammalian cells to detect specific cancer-related RNA markers. By genetically engineering these sensors, the goal is to deliver therapeutic proteins directly to cancer cells based on their unique transcriptional profiles. This innovative approach aims to enhance cancer treatment by not only targeting cancer cells for destruction but also training the immune system to recognize and eliminate other cancer cells. The methodology involves using genetic circuits that can sense cellular states and respond accordingly, potentially transforming cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with specific types of cancer that exhibit unique RNA markers.
Not a fit: Patients with cancers that do not have identifiable RNA markers or those who are not eligible for genetic therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted cancer treatments that minimize damage to healthy cells.
How similar studies have performed: Previous research has shown promise in using RNA-based approaches for cancer detection and treatment, indicating that this method could be a significant advancement in the field.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAO, XIAOJING J — STANFORD UNIVERSITY
- Study coordinator: GAO, XIAOJING J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Detection, Cancer Model, Cancer Treatment, Cancer cell line, CancerModel