Developing RNA aptamers using a special chemical modification
8-Oxo-7,8-dihydroguanosine in aptamer development and its impact on RNA structure Supplement
['FUNDING_R15'] · UNIVERSITY OF COLORADO DENVER · NIH-11032572
This study is exploring new ways to create special molecules that can target specific substances in the body, which could lead to better treatments and tests for patients.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11032572 on ClinicalTrials.gov |
What this research studies
This research focuses on creating RNA aptamers, which are molecules that can bind specifically to target substances, using a unique chemical modification called 8-oxo-7,8-dihydroguanosine. The researchers will employ advanced techniques like isothermal titration calorimetry to study how these aptamers interact with their targets, providing insights into their binding properties and affinities. This work aims to enhance the specificity and functionality of aptamers for potential therapeutic and biosensing applications. Patients may benefit from the development of more effective treatments and diagnostic tools based on these aptamers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that could be targeted by novel aptamer-based therapies.
Not a fit: Patients with conditions that do not involve molecular targets suitable for aptamer binding may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective therapeutic tools and diagnostic methods for patients.
How similar studies have performed: Previous research has shown success in developing aptamers using similar methodologies, indicating a promising avenue for further exploration.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RESENDIZ, MARINO JE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: RESENDIZ, MARINO JE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.