Developing protein-based therapies for targeting cells inside the body
Protein-based Self-assembly and Disassembly of Nanostructures
This study is working on a new way to help medicines made from proteins get inside cells to treat tough conditions, using tiny gel-like carriers that can deliver these treatments more effectively, which could change how we tackle certain diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project ID | NIH-11090031 on NIH RePORTER |
What this research studies
This research focuses on creating innovative platforms that allow protein-based biologics to effectively target and treat intracellular conditions. By developing a new system that encapsulates proteins in nanogels, the research aims to overcome the challenges of delivering these large molecules into cells, where they can engage specific targets that are currently difficult to reach with traditional small molecule drugs. The project will explore antibody-directed antibody conjugates (ADACs) to enhance the specificity and effectiveness of these treatments, potentially revolutionizing how certain diseases are treated at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with conditions that involve intracellular targets that are currently considered undruggable.
Not a fit: Patients with conditions that do not involve intracellular targets or those who are not responsive to biologic therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for diseases that currently lack adequate treatment options.
How similar studies have performed: While the approach of using protein-based biologics is established, the specific application of antibody-directed antibody conjugates for intracellular targeting is a novel area of exploration.
Where this research is happening
Hadley, United States
- University of Massachusetts Amherst — Hadley, United States (Active)
Researchers
- Principal investigator: Thayumanavan, Sankaran — University of Massachusetts Amherst
- Study coordinator: Thayumanavan, Sankaran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.