Developing powerful antibodies to fight HIV-1
Official title: Potent broadly neutralizing antibody development against the HIV-1 fusion peptide epitope
Funded at Massachusetts General Hospital · NIH-10933519 · Data updated 2026-11-12
This study is all about finding better ways to create antibodies that can fight the HIV-1 virus, which could lead to improved vaccines and treatments to help prevent new infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 21, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $757,390 |
| NIH project number | 5R01AI181684-02 |
| Project ID | NIH-10933519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk of HIV-1 infection or those living with HIV-1 who may benefit from improved therapeutic options.
✕Less likely to help
Patients who are not at risk for HIV-1 or those who are already effectively managing their HIV-1 infection with current therapies may not receive direct benefits from this research.
What this research studies
This research focuses on creating effective antibodies that can neutralize the HIV-1 virus, particularly targeting a specific part of the virus known as the fusion peptide. By understanding how these antibodies can be enhanced, the project aims to improve vaccine and therapeutic options for preventing HIV-1 infections. The researchers will use advanced techniques to identify and engineer antibodies with better potency and broader effectiveness against the virus. This work could lead to significant advancements in the fight against HIV-1, ultimately helping to reduce new infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for HIV-1, significantly reducing the rate of new infections.
How similar studies have gone: Previous research has shown promise in developing broadly neutralizing antibodies for HIV-1, indicating that this approach has potential for success.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Dekosky, Brandon James — Massachusetts General Hospital
- Study coordinator: Dekosky, Brandon James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.