Developing personalized therapies for neuroblastoma in children
NCI Pediatric In Vivo Testing Program: Neuroblastoma
['FUNDING_U01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10862829
This study is looking for better ways to treat children with neuroblastoma by figuring out the unique genetic features of their cancer, so they can create personalized therapies that work better for them.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10862829 on ClinicalTrials.gov |
What this research studies
This research focuses on improving treatment outcomes for children with neuroblastoma, a challenging cancer that often resists standard therapies. By utilizing patient-derived xenograft models, the team aims to identify specific genetic drivers of the disease and develop targeted therapies tailored to individual patients. The approach involves analyzing biomarkers to design effective immunotherapies, potentially leading to more successful treatment options. Patients may benefit from therapies that are specifically designed for their unique cancer profile.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with disseminated neuroblastoma who have not responded well to conventional treatments.
Not a fit: Patients with other types of cancer or those who are not diagnosed with neuroblastoma may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase cure rates for children with neuroblastoma by providing personalized treatment options.
How similar studies have performed: Previous research has shown promise in using patient-derived models to develop targeted therapies for various cancers, indicating a potential for success in this novel approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOSSE, YAEL P — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: MOSSE, YAEL P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents