Developing patient-derived models to test cancer treatments
Official title: University of Pennsylvania Patient-derived Xenograft Development and Trials Center
Funded at University of Pennsylvania · NIH-10881937 · Data updated 2026-11-12
This study at the University of Pennsylvania is working on creating special models that mimic human cancers to see how well different cancer treatments work, helping doctors find the best options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,009,106 |
| NIH project number | 5U54CA283759-02 |
| Project ID | NIH-10881937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children and adolescents under 15 years old diagnosed with acute myeloid leukemia or other malignancies.
✕Less likely to help
Patients with cancers not represented in the PDX models or those over 15 years of age may not benefit from this research.
What this research studies
The University of Pennsylvania's research focuses on creating patient-derived xenograft (PDX) models to evaluate how different cancer treatments work based on specific molecular characteristics. These models are designed to closely mimic human cancers, allowing researchers to better understand treatment responses. The project aims to enhance the use of these models within the research community and guide the development of early-phase clinical trials for various malignancies. By leveraging a dedicated facility and experienced personnel, the research seeks to improve the precision of cancer medicine.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients.
How similar studies have gone: Previous research has shown success with patient-derived xenograft models in cancer treatment evaluation, indicating a promising approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Carroll, Martin — University of Pennsylvania
- Study coordinator: Carroll, Martin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.