Developing nickel catalysts for efficient chemical reactions involving alkynes.
Official title: Rational Design of Nickel Catalysts for Directing Group-Assisted Alkyne Hydrofunctionalization
Funded at North Dakota State University · NIH-10974957 · Data updated 2026-11-12
This study is working on new ways to make chemical reactions better and more efficient, which could help create medicines and other important products that might benefit patients in the future.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Dakota State University NIH-funded |
| Lab location | 1 site (Fargo, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $431,400 |
| NIH project number | 1R15GM155845-01 |
| Project ID | NIH-10974957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals who require new or improved medications developed through advanced chemical synthesis techniques.
✕Less likely to help
Patients with conditions that do not involve the need for new drug development or those not affected by the chemical processes studied may not receive direct benefits.
What this research studies
This research focuses on creating nickel-based catalysts that enhance chemical reactions involving alkynes, specifically hydrofunctionalization with amines and alcohols. By utilizing directing groups to improve reaction efficiency and selectivity, the project aims to develop methods that allow for the efficient formation of carbon-heteroatom bonds. The approach combines advanced chemical synthesis techniques with innovative catalyst design, potentially leading to more effective and sustainable chemical processes. Patients may benefit indirectly through advancements in drug synthesis and medicinal chemistry resulting from these improved methods.
Why it matters
Potential benefit: If successful, this research could lead to more efficient drug synthesis processes, ultimately improving the availability and effectiveness of medications for patients.
How similar studies have gone: While nickel-catalyzed reactions have shown promise in chemical synthesis, this specific approach to alkyne hydrofunctionalization is relatively novel and has not been extensively tested.
Where this research is happening
-
North Dakota State University
Fargo, United States Active
Researchers
- Principal investigator: Zhao, Pinjing — North Dakota State University
- Study coordinator: Zhao, Pinjing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.