Developing new vascular grafts that can degrade and mimic natural blood vessels
Elastic, Degradable Vascular Grafts with Helical Microfibers
This study is looking at new, stretchy blood vessel replacements made from special fibers that can help improve blood flow when arteries are blocked, especially for people with diabetes or those who are older, by making sure they work well with the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10901938 on NIH RePORTER |
What this research studies
This research focuses on creating elastic and degradable vascular grafts made from helical microfibers that can be used to reroute blood flow when arteries are blocked. The approach aims to overcome the limitations of current grafts, which either require harvesting from the patient or do not integrate well with the body. By mimicking the natural structure of blood vessels, these grafts are designed to remodel and function like native arteries. The research will investigate how well these grafts can be populated by host cells and how they perform in patients with conditions like diabetes and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients requiring vascular grafts, particularly those with limited donor vessels or conditions like diabetes.
Not a fit: Patients who do not require vascular grafts or have no arterial occlusions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer vascular grafts that improve outcomes for patients with blocked arteries.
How similar studies have performed: Previous research has shown promise in using biodegradable materials for vascular grafts, indicating potential for success in this novel approach.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Wang, Yadong — Cornell University
- Study coordinator: Wang, Yadong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.