Developing new vaccines to elicit broadly neutralizing antibodies against HIV-1
Neutralizing Antibody Core
This study is looking for ways to make better vaccines that help the immune system fight HIV-1 by encouraging the body to produce special antibodies, and it invites patients to share their blood samples to help researchers learn more about how to improve these vaccines.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062374 on NIH RePORTER |
What this research studies
This research focuses on creating advanced vaccines that can stimulate the immune system to produce broadly neutralizing antibodies (bnAbs) against HIV-1. It involves assessing the effectiveness of novel mRNA-based immunogens in laboratory settings and analyzing patient serum samples to identify individuals with specific neutralizing antibody responses. The goal is to improve vaccine design and formulation strategies based on detailed measurements of antibody responses. Patients may contribute by providing serum samples, which will help in understanding how to enhance vaccine efficacy.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals living with HIV-1 who have specific neutralizing antibody responses.
Not a fit: Patients who are not infected with HIV-1 or do not have the relevant antibody responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against HIV-1.
How similar studies have performed: Previous research has shown promise in developing vaccines that elicit neutralizing antibodies, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Seaman, Michael Scott — Dana-Farber Cancer Inst
- Study coordinator: Seaman, Michael Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.