Developing new vaccines to combat antimicrobial resistant infections
Official title: Deciphering the amine/acetylation code of PNAG through comprehensive libraries of synthetic oligosaccharides for effective anti-microbial vaccines
Funded at Michigan State University · NIH-11049361 · Data updated 2026-11-12
This study is working on new vaccines to help protect people from infections caused by germs that don't respond to regular antibiotics, by focusing on a specific part of these germs that can help boost the immune system's response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | November 12, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $837,644 |
| NIH project number | 1R01AI182419-01A1 |
| Project ID | NIH-11049361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of infections caused by antimicrobial resistant bacteria.
✕Less likely to help
Patients who are not at risk for infections or those who do not respond to vaccines may not benefit from this research.
What this research studies
This research focuses on creating innovative vaccines to prevent infections caused by antimicrobial resistant microbes. It investigates a specific target called Poly-β-(1−6)-N-acetylglucosamine (PNAG), which is found on the surface of many harmful pathogens. The team will synthesize a variety of PNAG structures with different chemical modifications to understand how these variations affect the immune response. By linking these PNAG structures to a strong immunogenic carrier, the research aims to enhance the effectiveness of the vaccines in generating protective immunity.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines that protect against infections from antibiotic-resistant pathogens.
How similar studies have gone: Other research has shown promise in developing vaccines targeting similar virulence factors, indicating potential success for this approach.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Huang, Xuefei — Michigan State University
- Study coordinator: Huang, Xuefei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.