Developing new vaccines for HIV-1 using self-amplifying RNA technology
Official title: Project-002
Funded at Fred Hutchinson Cancer Center · NIH-11077323 · Data updated 2026-11-12
This study is testing two new vaccines for HIV that use a special technology to help your body recognize and fight the virus, and it aims to find a better way to prevent HIV infection for people at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 30, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $215,682 |
| NIH project number | 5U19AI174242-03 |
| Project ID | NIH-11077323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals at high risk for HIV infection or those living with HIV.
✕Less likely to help
Patients who are not at risk for HIV or those who are already receiving effective treatment for HIV may not benefit from this research.
What this research studies
This research focuses on creating two innovative vaccine candidates for HIV-1 that utilize self-amplifying RNA technology. The vaccines are designed to encode specific HIV-1 proteins, which will be delivered to cells using a specialized lipid carrier to enhance their effectiveness. The project includes rigorous manufacturing processes to ensure the vaccines meet safety and quality standards, as well as a stability program to monitor their effectiveness over time. Patients may benefit from these vaccines as they could provide a new approach to preventing HIV infection.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that significantly reduce the risk of HIV infection.
How similar studies have gone: Other research has shown promise with similar self-amplifying RNA vaccine approaches, particularly in the development of vaccines for other viral infections.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Stamatatos, Leonidas — Fred Hutchinson Cancer Center
- Study coordinator: Stamatatos, Leonidas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.