Developing new vaccines for HIV-1 using self-amplifying RNA technology
Project-002
This study is testing two new vaccines for HIV that use a special technology to help your body recognize and fight the virus, and it aims to find a better way to prevent HIV infection for people at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11077323 on NIH RePORTER |
What this research studies
This research focuses on creating two innovative vaccine candidates for HIV-1 that utilize self-amplifying RNA technology. The vaccines are designed to encode specific HIV-1 proteins, which will be delivered to cells using a specialized lipid carrier to enhance their effectiveness. The project includes rigorous manufacturing processes to ensure the vaccines meet safety and quality standards, as well as a stability program to monitor their effectiveness over time. Patients may benefit from these vaccines as they could provide a new approach to preventing HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals at high risk for HIV infection or those living with HIV.
Not a fit: Patients who are not at risk for HIV or those who are already receiving effective treatment for HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that significantly reduce the risk of HIV infection.
How similar studies have performed: Other research has shown promise with similar self-amplifying RNA vaccine approaches, particularly in the development of vaccines for other viral infections.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Stamatatos, Leonidas — Fred Hutchinson Cancer Center
- Study coordinator: Stamatatos, Leonidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.