Developing new types of antibodies from fish genes
Expressing a novel class of heavy chain antibodies
This study is exploring a new type of antibody from cartilaginous fish that could help develop better treatments for diseases by finding things that regular antibodies might overlook, and it's being tested using specially created mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-10555257 on NIH RePORTER |
What this research studies
This research focuses on creating a novel class of heavy chain antibodies (HCAbs) derived from cartilaginous fish. These antibodies are unique because they do not require a light chain partner, allowing for greater flexibility and potential in drug development and immunotherapy. The project involves generating transgenic mice that express these fish antibody genes and testing their ability to recognize various immunogens. This approach aims to uncover new antigenic determinants that traditional antibodies may miss.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that could be targeted by novel immunotherapies.
Not a fit: Patients with conditions that do not respond to antibody-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective immunotherapies and treatments for various diseases.
How similar studies have performed: While the use of heavy chain antibodies is a relatively novel approach, there have been successful applications of similar methodologies in immunotherapy.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Hsu, Ellen — Suny Downstate Medical Center
- Study coordinator: Hsu, Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.