Developing new treatments to reduce pain from arthritis
Official title: BCCMA: Cartilage Repair Strategies to Alleviate Arthritis Pain (Care AP): Targeting Pattern-Recognition to Reduce Pain-Related Pathology in Osteoarthritis
Funded at Philadelphia VA Medical Center · NIH-11109568 · Data updated 2026-11-12
This study is looking for new ways to help military service members and veterans with post-traumatic osteoarthritis by finding treatments that reduce pain and inflammation in their joints, using special cells to heal damaged cartilage, and exploring how a specific receptor affects their symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX004912-04 |
| Project ID | NIH-11109568 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military service members and veterans who are experiencing pain and functional limitations due to post-traumatic osteoarthritis.
✕Less likely to help
Patients with osteoarthritis not related to trauma or those who do not have significant pain or functional impairment may not benefit from this research.
What this research studies
This research focuses on finding effective treatments for post-traumatic osteoarthritis (PTOA), a condition common among military service members and veterans. The approach involves developing innovative therapies that target inflammation and pain in the joints, as well as optimizing the use of mesenchymal stem cells to repair damaged cartilage. By understanding the role of a specific receptor, CD14, in pain and inflammation, the research aims to create non-drug therapies that can improve joint function and reduce discomfort for patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly alleviate arthritis pain and improve the quality of life for patients suffering from PTOA.
How similar studies have gone: Previous research has shown promise in targeting inflammation and pain in osteoarthritis, but this specific approach focusing on CD14 is relatively novel.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Scanzello, Carla Rose — Philadelphia VA Medical Center
- Study coordinator: Scanzello, Carla Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.