Developing new treatments to prevent relapse in substance use disorders.
Official title: MRI GLOBAL - MILLER DMFP
Funded at Midwest Research Institute · NIH-10910952 · Data updated 2026-11-12
This study is testing new medications to help people with substance use disorders by looking at how these drugs can change brain activity and reduce cravings, all while using advanced imaging technology to see how well they work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Midwest Research Institute NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 20, 2019 |
| Project end | January 31, 2027 |
| Funding year | 2023 |
| Award (this year) | $1,311,541 |
| NIH project number | 271201500006I-P00004-759501900088-1 |
| Project ID | NIH-10910952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of substance use disorders who are currently in recovery or at risk of relapse.
✕Less likely to help
Patients who are not currently experiencing substance use issues or those who have not previously struggled with substance use disorders may not benefit from this research.
What this research studies
This research focuses on creating nonmuscle II inhibitors aimed at preventing relapse in individuals struggling with substance use disorders. By utilizing advanced magnetic resonance imaging (MRI) techniques, the study seeks to understand how these inhibitors can affect brain function and behavior related to substance use. Patients may be involved in trials that assess the effectiveness of these new treatments in reducing cravings and preventing relapse. The approach combines innovative drug development with cutting-edge imaging technology to provide insights into treatment efficacy.
Why it matters
Potential benefit: If successful, this research could lead to new medications that significantly reduce the risk of relapse for individuals recovering from substance use disorders.
How similar studies have gone: Other research has shown promise in using similar approaches to develop treatments for substance use disorders, indicating potential for success in this area.
Where this research is happening
-
Midwest Research Institute
Kansas City, United States Active
Researchers
- Principal investigator: Slade, Desmond — Midwest Research Institute
- Study coordinator: Slade, Desmond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.